Chloroacetone → 1-(3-Bromo-4-fluorophenylthio)propan-2-one
反応式
[Br:1][C:2]1[CH:3]=[C:4]([SH:9])[CH:5]=[CH:6][C:7]=1[F:8].Cl[CH2:11][C:12](=[O:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]([S:9][CH2:11][C:12](=[O:14])[CH3:13])[CH:5]=[CH:6][C:7]=1[F:8]参加物
5
実験手順
Using analogous reagents and reaction conditions as described in Example 24 for the preparation of I-24a above, 3-bromo-4-fluoro-benzenethiol (2.0 g, 9.756 mmol) was reacted with 1-chloro-propan-2-one (0.86 mL, 10.73 mmol), DMF (6.0 mL), and potassium carbonate (2.69 g, 19.51 mmol) to afford crude product which was purified by column on silica gel (5% ethyl acetate in hexane) to afford 2.1 g of the product (82% yield).
後処理
- customreagents and reaction conditions
- customto afford crude product which
- customwas purified by column on silica gel (5% ethyl acetate in hexane)
出典と根拠
- ORDレコード
- ord-48037dd1bf4f49cdbfd4f9ecd5168ec3
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09339501B2
反応ノート
読み込み中…