1-(3-Bromo-4-fluorophenylthio)propan-2-one → 6-Bromo-5-fluoro-3-methylbenzo[b]thiophene
反応式
[Br:1][C:2]1[CH:3]=[C:4]([S:9][CH2:10][C:11](=O)[CH3:12])[CH:5]=[CH:6][C:7]=1[F:8]>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:7]([F:8])=[CH:6][C:5]2[C:11]([CH3:12])=[CH:10][S:9][C:4]=2[CH:3]=1参加物
3
実験手順
Using analogous reagents and reaction conditions as described in Example 24 for the preparation of I-24b above, 1-(3-bromo-4-fluoro-phenylsulfanyl)-propan-2-one (I-29a: 2.1 g, 8.015 mmol) in toluene (10 mL) was cyclized with polyphosphoric acid (8 g) to yield crude product which was purified by column chromatography on silica gel (100% hexane) to afford 1.4 g of product (72% yield).
後処理
- customreagents and reaction conditions
- customto yield crude product which
- customwas purified by column chromatography on silica gel (100% hexane)
出典と根拠
- ORDレコード
- ord-c8b515f4d1a04a249ebfc7d37530b64d
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09339501B2
反応ノート
読み込み中…