Hydrochloric Acid → 2-(2-Methoxypyridin-4-yl)-2,4-diazabicyclo[3.1.0]hexan-3-one
反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N:9]2[CH:14]3[CH:12]([CH2:13]3)[N:11](C(OCC3C=CC=CC=3)=O)[C:10]2=[O:25])[CH:6]=[CH:5][N:4]=1.Cl>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N:9]2[C:10](=[O:25])[NH:11][CH:12]3[CH:14]2[CH2:13]3)[CH:6]=[CH:5][N:4]=1参加物
3
実験手順
Using analogous reagents and reaction conditions as described in Example 30 for the preparation of I-30c above, benzyl 4-(2-methoxypyridin-4-yl)-3-oxo-2,4-diazabicyclo[3.1.0]hexane-2-carboxylate (150.0 mg, 0.442 mmol) was treated with 10.0 mL of 6N HCl to yield the crude product. Purification by column chromatography on silica gel (1.5% methanol in chloroform) afforded 60 mg of the product (67% yield).
後処理
- customreagents and reaction conditions
- customto yield the crude product
- customPurification by column chromatography on silica gel (1.5% methanol in chloroform)
出典と根拠
- ORDレコード
- ord-61d95f7f5f704109afbfd1fe0e9b4140
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09339501B2
反応ノート
読み込み中…