Ethyl Acetate → HCID 70981944、化合物

HRID 523591ノート

反応式

HRID 523591 の反応式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[CH2:12][CH2:11][CH2:10][CH:9]=1.C(OCC)(=O)C>C1(C)C=CC=CC=1.CCCCCC.[Pt]=O>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1

参加物

6

反応物 2

HCID 8857Ethyl AcetateHCID 709821203-Bromo-4-cyclopent-1-enyl-pyridine

生成物 1

HCID 70981944HCID 70981944、化合物収率 71%

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 1140Toluene溶媒HCID 8058Hexane溶媒

実験手順

Platinum oxide (20 mg) was added to a mixture of 3-bromo-4-cyclopent-1-enyl-pyridine (I-34b: 140 mg, 0.622 mmol) in toluene (5 mL) and stirred overnight under hydrogen atmosphere. The reaction was monitored by TLC (20% ethyl acetate in hexane). The reaction mixture was filtered through celite pad and washed with toluene and concentrated to afford crude product. Purification by column chromatography (8% ethyl acetate in hexane) afforded 98 mg of the product (71% yield).

後処理

  1. filtrationThe reaction mixture was filtered through celite pad
  2. washwashed with toluene
  3. concentrationconcentrated
  4. customto afford crude product
  5. customPurification by column chromatography (8% ethyl acetate in hexane)

出典と根拠

ORDレコード
ord-d3eeadd28e1747978832e2646d230272
出典データセット
uspto-grants-2016_05
特許番号
US09339501B2

反応ノート

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