Hydrochloric Acid → HCID 11186874、化合物

HRID 523790ノート

反応式

HRID 523790 の反応式
C[O:2][C:3](=[O:25])[CH2:4][NH:5][C:6]([C:8]1[N:9]=[C:10]([Cl:24])[C:11]2[C:16]([C:17]=1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:7].Cl.C([O-])(O)=O.[Na+]>>[Cl:24][C:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:8]([C:6]([NH:5][CH2:4][C:3]([OH:25])=[O:2])=[O:7])[N:9]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 86014604HCID 86014604、化合物

生成物 1

HCID 11186874HCID 11186874、化合物収率 73.4%

実験手順

A mixture of [(1-chloro-4-phenyl-isoquinoline-3-carbonyl)-amino]-acetic acid methyl ester (50 mg, 0.14 mmol, Example D-74 b), and aqueous 6N HCl was stirred at ambient temperature for 11 days before the solution was neutralized by the addition of concentrated aqueous NaHCO3. The mixture was extracted with EtOAc (50 ml). The organic phase was dried over MgSO4 and concentrated in vacuo to give the title compound as a white solid (35 mg); MS-(+)-ion: M+1=341.0.

後処理

  1. extractionThe mixture was extracted with EtOAc (50 ml)
  2. dry with materialThe organic phase was dried over MgSO4
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-67adf44049734c0a983331f7559e168c
出典データセット
uspto-grants-2016_05
特許番号
US09339527B2

反応ノート

読み込み中…