6-Chlorohexanenitrile → S-(5-cyanopentyl)isothiourea hydrochloride

HRID 523856ノート

反応式

HRID 523856 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]#[N:8].[NH2:9][C:10]([NH2:12])=[S:11]>O>[ClH:1].[C:7]([CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][S:11][C:10](=[NH:9])[NH2:12])#[N:8]

参加物

4

反応物 2

HCID 2465226-ChlorohexanenitrileHCID 2723790Thiourea

生成物 1

HCID 86647988S-(5-cyanopentyl)isothiourea hydrochloride

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The 6-chlorohexanenitrile (6.36 g, 48.3 mmol) and thiourea (4.04 g, 53.1 mmol) are mixed in 40 ml of water. The mixture is heated to reflux for 3 to 4 hours. The reaction mixture is evaporated and 20 ml of ethanol is added and then evaporated as well. This is repeated three times. After that, 10 ml of methanol and 30 ml of acetone are added and the mixture is stirred for one hour. The crystalline material is filtered and the product is dried under high vacuum overnight to yield S-(5-cyanopentyl)isothiourea hydrochloride.

後処理

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 3 to 4 hours
  3. customThe reaction mixture is evaporated
  4. addition20 ml of ethanol is added
  5. customevaporated as well
  6. additionAfter that, 10 ml of methanol and 30 ml of acetone are added
  7. filtrationThe crystalline material is filtered
  8. customthe product is dried under high vacuum overnight

出典と根拠

ORDレコード
ord-99efc859cf0b47c6b7487b80f595d1ae
出典データセット
uspto-grants-2016_05
特許番号
US09340491B2

反応ノート

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