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N-bromobutanimide → 2-Amino-5-bromo-4-methoxybenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 2-Amino-4-methoxybenzaldehyde | HCID 323503 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Amino-5-bromo-4-methoxybenzaldehyde | HCID 59325258 | 56% |
反応手順
To a stirred solution of 2-amino-4-methoxybenzaldehyde (6 g, 39.7 mmol) in dichloromethane (100 mL) was added N-bromosuccinimide (7 g, 39.7 mmol). LCMS monitored the reaction until the starting material consumed completely. The reaction mixture was diluted with dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give the title compound (5 g, 56%) as a yellow solid. MS (ES+) C8H8BrNO2 requires: 229, 231. found: 230, 232 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340514B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-155398206c3b4298ade26f276c7a08a2 |
| 出典メモ | uspto-grants-2016_05 |