(2-Amino-5-bromo-3-fluorophenyl)methanol → 2-Amino-5-bromo-3-fluorobenzaldehyde

HRID 524078

反応式

HRID 524078 の反応式
[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH2:10][OH:11]>ClCCl.[O-2].[Mn+2]>[NH2:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([Br:9])=[CH:4][C:3]=1[CH:10]=[O:11]

参加物

4

反応物 1

HCID 54312525(2-Amino-5-bromo-3-fluorophenyl)methanol

生成物 1

HCID 542514502-Amino-5-bromo-3-fluorobenzaldehyde収率 85%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of (2-amino-5-bromo-3-fluorophenyl)methanol (13 g, 59.4 mmol) and manganese oxide (31 g, 356.4 mmol) in dichloromethane (400 mL) was stirred at RT overnight. TLC showed the starting material consumed completely. The solid was filtered off, and the filtrate was concentrated to give the title compound (11 g, 85%) as a light yellow solid, which was directly used in the next step without further purification.

後処理

  1. customconsumed completely
  2. filtrationThe solid was filtered off
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-b97d07b899804540be38b71d5efebbd3
出典データセット
uspto-grants-2016_05
特許番号
US09340514B2

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