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2,4-Difluoroaniline → 2,4-Difluorophenyl-3-methylurea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Difluoroaniline | HCID 9709 | — |
| 反応物 | Methyl Isocyanate | HCID 12228 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2,4-Difluorophenyl-3-methylurea | HCID 21161590 | — |
反応手順
Methyl isocyanate (9.6 g, 10 mL, 0.174 mol) is added to a solution of 2,4-difluoroaniline (15 g, 0.116 mol) in toluene. The reaction mixture is stirred for 1 hour and filtered to obtain a solid. The solid is washed with hexanes and air-dried to give the title product as an off-white solid, mp 182°-183° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616706 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-90e45d1aa551449696b282c92fa6a0b5 |
| 出典メモ | uspto-grants-1997_04 |