化工社化工社 化学情報印刷レポート · 研究参考用
o-Toluenesulfonyl chloride → 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-{1-[(2-methylphenyl)sulfonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | o-Toluenesulfonyl chloride | HCID 8623 | — |
| 反応物 | 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-piperidin-4-yl-2,4-dihydro-3H-pyrazol-3-one hydrochloride | HCID 66616406 | — |
| 生成物 | 5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-{1-[(2-methylphenyl)sulfonyl]piperidin-4-yl}-2,4-dihydro-3H-pyrazol-3-one | HCID 46202394 | — |
反応手順
The title compound is prepared analogously as described for GP1 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B1*HCl) and 2-methylbenzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340522B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-25b21c802ac944dea1dd9b43e2775616 |
| 出典メモ | uspto-grants-2016_05 |