関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | 4'-Chloro-2'-fluoroacetanilide | HCID 853174 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | N-(4-chloro-2-fluoro-5-nitrophenyl)acetamide | HCID 13563753 | — |
反応手順
A mixture of 4'-chloro-2'-fluoroacetanilide (51 g, 0.272 mol) in concentrated sulfuric acid (100 mL) is cooled to 0° C., treated with nitric acid (90% real, 14 mL, 0.300 mol) over 45 minutes, stirred for 10 minutes, and poured onto ice. The resultant aqueous mixture is filtered to obtain a tan solid which is washed with water, dried overnight, and recrystallized from a chloroform/hexanes (17:1) solution to give the title product as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05616706 |
|---|
| 出典データセット | uspto-grants-1997_04 |
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| ORD ID | ord-0cd1ecb239064c08a4fed2b0b4735106 |
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| 出典メモ | uspto-grants-1997_04 |
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