Bromine → 5-Bromo-1-cyclobutyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide

HRID 524333ノート

反応式

HRID 524333 の反応式
BrC1C(=O)C(C(O)=O)=CN(C(C)C)C=1C.[Br:16][C:17]1[C:18](=[O:31])[C:19]([C:28]([OH:30])=O)=[CH:20][N:21]([CH:24]2[CH2:27][CH2:26][CH2:25]2)[C:22]=1[CH3:23].Cl.CS(C1C=CC(CN)=CC=1)(=O)=O.[CH3:45][S:46]([C:49]1[CH:50]=[CH:51][C:52]([CH2:55][NH2:56])=[N:53][CH:54]=1)(=[O:48])=[O:47].BrBr>>[CH3:45][S:46]([C:49]1[CH:50]=[CH:51][C:52]([CH2:55][NH:56][C:28]([C:19]2[C:18](=[O:31])[C:17]([Br:16])=[C:22]([CH3:23])[N:21]([CH:24]3[CH2:25][CH2:26][CH2:27]3)[CH:20]=2)=[O:30])=[N:53][CH:54]=1)(=[O:48])=[O:47]

参加物

6

反応物 5

HCID 24408BromineHCID 27292694-Methylsulfonylbenzylamine hydrochlorideHCID 57354332(5-(Methylsulfonyl)pyridin-2-yl)methanamineHCID 867115775-Bromo-1-isopropyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acidHCID 867115825-Bromo-1-cyclobutyl-6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid

生成物 1

HCID 867115815-Bromo-1-cyclobutyl-6-methyl-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid (5-methanesulfonyl-pyridin-2-ylmethyl)-amide

実験手順

Preparation 18 is prepared following the procedure for preparation 5, substituting preparation 3c with preparation 7b and 4-methylsulfonylbenzylamine hydrochloride with C-(5-methanesulfonyl-pyridin-2-yl)-methylamine. ESI mass spectrum: [M+H]+=454 (bromine isotope pattern); Retention time HPLC: 1.14 min (Z002_006).

後処理

  1. customPreparation 18
  2. customis prepared
  3. customfor preparation 5

出典と根拠

ORDレコード
ord-aff637d6df194ea29ec0e7bda4d65b3e
出典データセット
uspto-grants-2016_05
特許番号
US09340507B2

反応ノート

読み込み中…