HCID 19963711、化合物 → HCID 19963713、化合物

HRID 52438ノート

反応式

HRID 52438 の反応式
[CH3:1][C:2]1([CH3:19])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[C:13][Si](C)(C)C)[CH:10]=2)[NH:5][C:4](=[O:18])[CH2:3]1>CO>[CH3:1][C:2]1([CH3:19])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]#[CH:13])[CH:10]=2)[NH:5][C:4](=[O:18])[CH2:3]1

参加物

3

反応物 1

HCID 19963711HCID 19963711、化合物2 回

生成物 1

HCID 19963713HCID 19963713、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2.64 g (9.7 mmol) of 4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6[(trimethylsilyl)ethynyl]quinoline (Compound 2) in 200 ml of methanol was added 0.269 g (1.95 mmol) of K2CO3The reaction was stirred at room temperature for 12 h. The reaction was then concentrated in vacuo and water was added to the residue. The aqueous layer was extracted with methylene chloride (2×). The organic layers were dried (MgSO4), filtered and concentrated in vacuo to give the title compound as a white solid.

後処理

  1. concentrationThe reaction was then concentrated in vacuo and water
  2. additionwas added to the residue
  3. extractionThe aqueous layer was extracted with methylene chloride (2×)
  4. dry with materialThe organic layers were dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-30f595256a6247b692fae42f1712eea2
出典データセット
uspto-grants-1997_04
特許番号
US05616712

反応ノート

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