Potassium Carbonate → 4,4-Dimethyl-2-iso-propoxy-3,4-dihydro-7-ethynylquinoline

HRID 52448ノート

反応式

HRID 52448 の反応式
[CH3:1][C:2]1([CH3:22])[C:11]2[C:6](=[CH:7][C:8]([C:12]#[C:13][Si](C)(C)C)=[CH:9][CH:10]=2)[NH:5][CH:4]([O:18][CH:19]([CH3:21])[CH3:20])[CH2:3]1.C(=O)([O-])[O-].[K+].[K+]>CO>[CH3:1][C:2]1([CH3:22])[C:11]2[C:6](=[CH:7][C:8]([C:12]#[CH:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([O:18][CH:19]([CH3:20])[CH3:21])[CH2:3]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 199637264,4-Dimethyl-2-iso-propoxy-1,2,3,4-tetrahydro-7-[(trimethylsilyl)ethynyl]quinoline2 回

生成物 1

HCID 199637244,4-Dimethyl-2-iso-propoxy-3,4-dihydro-7-ethynylquinoline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 0.14 g (0.45 mmol) of 4,4-dimethyl-2-iso-propoxy-1,2,3,4-tetrahydro-7-[(trimethylsilyl)ethynyl]quinoline (Compound 26) in 2.5 ml of methanol was added 0.10 g (0.72 mmol) of potassium carbonate. The reaction mixture was then stirred at room temperature for 2.5 h. The reaction mixture was then concentrated in vacuo and the resulting oil was dissolved in water and extracted with methylene chloride (2×). The organic layers were dried (MgSO4), filtered and concentrated in vacuo to give the title compound as an oil. This compound was used for the next reaction without further purification.

後処理

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. dissolutionthe resulting oil was dissolved in water
  3. extractionextracted with methylene chloride (2×)
  4. dry with materialThe organic layers were dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-3b49daf3eaa64ffa90521ef7140c9676
出典データセット
uspto-grants-1997_04
特許番号
US05616712

反応ノート

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