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1-Iodoheptane → Ethyl 4-[(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-1-heptyl-6-quinolinyl)ethynyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Iodoheptane | HCID 20274 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl 4-[(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-1-iso-propyl-6-quinolinyl)ethynyl]benzoate | HCID 19963717 | — |
| 反応物 | 4-[(4,4-Dimethyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)ethynyl]benzoate | HCID 19963738 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Ethyl 4-[(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-1-heptyl-6-quinolinyl)ethynyl]benzoate | HCID 19963740 | — |
反応手順
NaH (98.4 mg, 2.7 mmol), ethyl 4-[(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl )ethynyl]benzoate (Compound 4, 635 mg, 1.8 mmol) and iodo heptane (2.73 mL, 18 mmol) in 3 mL of DMF were reacted substantially in accordance with the procedure used for the preparation of ethyl 4-[(4,4-dimethyl-2-oxo-1,2,3,4-tetrahydro-1-iso-propyl-6-quinolinyl)ethynyl]benzoate (Compound 5), to give the title compound as white solids.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616712 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-1d925642ef7545ff9ad20b50eaa3c39d |
| 出典メモ | uspto-grants-1997_04 |