Hydrochloric Acid → 3-Morpholin-3-yl-propionic acid hydrochloride

HRID 524580ノート

反応式

HRID 524580 の反応式
C(OC([N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[CH2:14][CH2:15][C:16]([OH:18])=[O:17])=O)(C)(C)C.[ClH:19]>CCOC(C)=O>[ClH:19].[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH:9]1[CH2:14][CH2:15][C:16]([OH:18])=[O:17]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 534250424-Boc-3-(2-carboxy-ethyl)-morpholine

生成物 1

HCID 900433373-Morpholin-3-yl-propionic acid hydrochloride収率 90%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

反応条件

温度
25 °C

実験手順

To a solution of 3-(4-(tert-butoxycarbonyl)morpholin-3-yl)propanoic acid (0.3 g, 1.2 mmol) in EtOAc (2 mL) was added the solution of HCl in EtOAc (6 mol/L, 6 mL). The mixture was stirred closedly at 25° C. for 2 hours and filtered. The residue was washed with EtOAc (4 mL) to give the title compound as a white solid (0.21 g, 90%). The compound was characterized by the following spectroscopic data:

後処理

  1. filtrationfiltered
  2. washThe residue was washed with EtOAc (4 mL)

出典と根拠

ORDレコード
ord-115f5f3c27054f1f957714721490271c
出典データセット
uspto-grants-2016_05
特許番号
US09340538B2

反応ノート

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