Morpholine-3-carboxamide → HCID 73294949、化合物

HRID 524591

反応式

HRID 524591 の反応式
Br[CH2:2][C:3]1[NH:8][C:7]([C:9]2[S:10][CH:11]=[CH:12][N:13]=2)=[N:6][CH:5]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=2[Cl:21])[C:4]=1[C:22]([O:24][CH2:25][CH3:26])=[O:23].[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH:28]1[C:33]([NH2:35])=[O:34]>>[C:33]([CH:28]1[N:27]([CH2:2][C:3]2[NH:8][C:7]([C:9]3[S:10][CH:11]=[CH:12][N:13]=3)=[N:6][CH:5]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:15]=3[Cl:21])[C:4]=2[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:32][CH2:31][O:30][CH2:29]1)(=[O:34])[NH2:35]

参加物

3

反応物 2

HCID 19792002Morpholine-3-carboxamideHCID 118107510Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate

生成物 1

HCID 73294949HCID 73294949、化合物収率 49%

実験手順

Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (2.85 g, 6 mmol) was reacted with morpholine-3-carboxamide (0.78 g, 6 mmol) according to the procedure as described in Example 25, Step B to give the title compound as a yellow solid (1.54 g, 49%). The compound was characterized by the following spectroscopic data:

出典と根拠

ORDレコード
ord-004aecd12c014c4e9bb133c6582e3fe3
出典データセット
uspto-grants-2016_05
特許番号
US09340538B2

関連ノート

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