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3-Morpholinecarboxylic acid → HCID 90043251、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Morpholinecarboxylic acid | HCID 3340152 | — |
| 反応物 | Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(1,3,4-thiadiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 90043754 | — |
| 生成物 | HCID 90043251 | HCID 90043251 | 56% |
反応手順
Ethyl 6-(bromomethyl)-4-(2,4-dichlorophenyl)-2-(1,3,4-thiadiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate (0.7 g, 1.5 mmol) was reacted with morpholine-3-carboxylic acid (0.2 g, 1.5 mmol) according to the procedure as described in Example 1, Step C to give the title compound as a yellow solid (0.44 g, 56%). The compound was characterized by the following spectroscopic data:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340538B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-c3e072d42c294a39b275f74452168be5 |
| 出典メモ | uspto-grants-2016_05 |