Ammonium Chloride → Methyl 2-(3-carbamimidoyl-1H-1,2,4-triazol-1-yl)acetate hydrochloride
反応式
[C:1]([C:3]1[N:7]=[CH:6][N:5]([CH2:8][C:9]([O:11][CH2:12]C)=[O:10])[N:4]=1)#[N:2].C[O-].[Na+].[Cl-:17].[NH4+:18]>>[ClH:17].[C:1]([C:3]1[N:7]=[CH:6][N:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[N:4]=1)(=[NH:2])[NH2:18]参加物
4
実験手順
Ethyl 2-(3-cyano-1H-1,2,4-triazol-1-yl)acetate (2 g, 11.2 mmol) was reacted with sodium methoxide (0.85 g, 15.68 mmol) and ammonium chloride (0.89 g, 16.8 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (1.35 g, 55%). The compound was characterized by the following spectroscopic data:
出典と根拠
- ORDレコード
- ord-002c5003137c447c984d7d10eac4f92b
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09340538B2
反応ノート
読み込み中…