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Ethyl Acetoacetate → Ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(pyrazin-2-yl)-1,4-dihydropyrimidine-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetoacetate | HCID 8868 | — |
| 反応物 | 2-Chloro-4-fluorobenzaldehyde | HCID 145024 | — |
| 反応物 | Pyrazine-2-carboxamidine hydrochloride | HCID 470895 | — |
| 生成物 | Ethyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(pyrazin-2-yl)-1,4-dihydropyrimidine-5-carboxylate | HCID 118107549 | 41% |
反応手順
Pyrazine-2-carboximidamide hydrochloride (5 g, 31.5 mmol) was reacted with 2-chloro-4-fluorobenzaldehyde (5 g, 31.5 mmol) and ethyl 3-oxobutanoate (4.1 g, 31.5 mmol) according to the procedure as described in Example 1, Step A to give the title compound as a yellow solid (4.84 g, 41%). The compound was characterized by the following spectroscopic data:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340538B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-2df5724b920746949c2d5f84a29dc7d2 |
| 出典メモ | uspto-grants-2016_05 |