Ammonium Chloride → 5-Methoxythiazole-2-carboximidamide hydrochloride

反応式

[CH3:1][O:2][C:3]1[S:7][C:6]([C:8]#[N:9])=[N:5][CH:4]=1.C[O-].[Na+].[Cl-:13].[NH4+:14]>>[ClH:13].[CH3:1][O:2][C:3]1[S:7][C:6]([C:8](=[NH:14])[NH2:9])=[N:5][CH:4]=1

参加物

反応物 3

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 900443835-Methoxythiazole-2-carbonitrile

生成物 1

HCID 900443915-Methoxythiazole-2-carboximidamide hydrochloride収率 50.1%

実験手順

5-methoxythiazole-2-carbonitrile (0.74 g, 5.26 mmol) was reacted with sodium methoxide (0.28 g, 5.26 mmol) and ammonium chloride (0.6 g, 11 mmol) according to the procedure as described in Example 61, Step B to give the title compound as a white solid (0.51 g, 50%). The compound was characterized by the following spectroscopic data:

出典と根拠

ORDレコード: ord-0acb2cb2b6f34530ada9a9277acb8d23
出典データセット: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09340538B2

反応ノート

読み込み中…