Hydrochloric Acid → 3-Bromo-4-chloro-5-fluoropyridine hydrochloride

HRID 524883ノート

反応式

HRID 524883 の反応式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[Cl:8].Cl>CCCCC>[ClH:8].[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([F:9])[C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 709772193-Bromo-4-chloro-5-fluoropyridine

生成物 1

HCID 867209403-Bromo-4-chloro-5-fluoropyridine hydrochloride収率 120.6%

試薬・触媒・溶媒 1

HCID 8003Pentane溶媒

実験手順

To a solution of 3-bromo-4-chloro-5-fluoro-pyridine (7.56 g, 32.18 mmol) in pentane (100 mL) was added hydrogen chloride (2M in ether) (17.7 mL of 2 M, 35.4 mmol). An off-white precipitate formed instantly. The mixture was stirred for 5 minutes then the solid was collected by filtration, washed with pentane and dried by suction to afford the desired product as an off-white solid (4.79 g, 60%). 1H NMR (DMSO-d6) δ 8.77 (s, 1H), 8.75 (s, 1H).

後処理

  1. customAn off-white precipitate formed instantly
  2. filtrationthe solid was collected by filtration
  3. washwashed with pentane
  4. customdried by suction

出典と根拠

ORDレコード
ord-c8dea6efc6e74c3a9f924dc42fb3f8c6
出典データセット
uspto-grants-2016_05
特許番号
US09340546B2

反応ノート

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