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2-(((Tert-butoxy)carbonyl)amino)butanoic acid → tert-Butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(((Tert-butoxy)carbonyl)amino)butanoic acid | HCID 333522 | — |
| 反応物 | 1-amino-N-phenyl-1H-pyrrole-2-carboxamide | HCID 70922454 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | tert-Butyl 1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)propan-2-ylcarbamate | HCID 70922143 | 87.6% |
反応手順
The title compound was prepared following the experimental procedure described in preparation 20a from 1.50 g (7.45 mmol) of 1-amino-N-phenyl-1H-pyrrole-2-carboxamide and 1.82 g (8.95 mmol) of racemic 2-(tert-butoxycarbonylamino)butanoic acid (purchased from ABCR, cat. no. AB154485). After recristallysation of the crude product in diethylether, 2.43 g (84% yield) of the title compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340547B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-2c32fb8c08414f52acc2d661f579da4b |
| 出典メモ | uspto-grants-2016_05 |