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HRID 525010作成日：2026年10月26日

2-Pyridinemethanamine → (S)-tert-Butyl 1-(3-bromo-2-(pyridin-2-ylmethylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate

https://huagongshe.com/reaction/525010

反応式

関与物質

役割名称HCID仕込み量
反応物2-PyridinemethanamineHCID 19509—
反応物(S)-Methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylateHCID 86722018—
生成物(S)-tert-Butyl 1-(3-bromo-2-(pyridin-2-ylmethylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamateHCID 86722030—

反応手順

Same procedure as described in preparation 133a was used from (S)-methyl 3-bromo-1-(2-(tert-butoxycarbonylamino)propanamido)-1H-pyrrole-2-carboxylate (374 mg, 0.96 mmols) and pyridine-2-ylmethanamine (0.30 ml, 2.87 mmols). After reverse phase chromatography the title compound was obtained (74 mg, 17%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09340547B2
出典データセットuspto-grants-2016_05
ORD IDord-7924540c81e04da7a4c919b93d5390ce
出典メモuspto-grants-2016_05