Tert-butoxycarbonylalanine → HCID 86722036、化合物

反応式

[NH2:1][N:2]1[CH:6]=[CH:5][C:4]([Br:7])=[C:3]1[C:8]([NH:10][C:11]1[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=1)=[O:9].[C:19]([O:23][C:24]([NH:26][C@@H:27]([CH3:31])[C:28](O)=[O:29])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[Br:7][C:4]1[CH:5]=[CH:6][N:2]([NH:1][C:28](=[O:29])[C@@H:27]([NH:26][C:24](=[O:25])[O:23][C:19]([CH3:21])([CH3:20])[CH3:22])[CH3:31])[C:3]=1[C:8](=[O:9])[NH:10][C:11]1[CH:16]=[C:15]([F:17])[CH:14]=[C:13]([F:18])[CH:12]=1

参加物

反応物 2

HCID 85082Tert-butoxycarbonylalanine

HCID 70978853HCID 70978853、化合物

生成物 1

HCID 86722036HCID 86722036、化合物収率 54.4%

実験手順

The title compound was prepared from 1-amino-3-bromo-N-(3,5-difluorophenyl)-1H-pyrrole-2-carboxamide (7.87 g, 24.9 mmol) and (S)-2-(tert-butoxycarbonylamino)propanoic acid (purchased from Aldrich, 5.65 g, 29.9 mmol) following the experimental procedure described in Preparation 45a. 6.6 g (51% yield) of the desired compound were obtained.

出典と根拠

ORDレコード: ord-c0a8a6dfa2e94de692b22eea1146b42a
出典データセット: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09340547B2

反応ノート

読み込み中…