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N-carbobenzyloxyalanine → (S)-Methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-Bromo-1H-Pyrrole-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-carbobenzyloxyalanine | HCID 736104 | — |
| 反応物 | methyl 1-amino-3-bromo-1H-pyrrole-2-carboxylate | HCID 70979762 | — |
| 生成物 | (S)-Methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-Bromo-1H-Pyrrole-2-carboxylate | HCID 86722049 | 89.6% |
反応手順
The title compound was prepared from methyl 1-amino-3-bromo-1H-pyrrole-2-carboxylate (9.05 g, 25.6 mmol) and (S)-2-(benzyloxycarbonylamino)propanoic acid (5.72 g, 25.6 mmol) following the experimental procedure described in Preparation 73a. 9.73 g (84% yield) of the desired compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340547B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-b2e06ac5adc74ca9a1c9c1efe94f92a2 |
| 出典メモ | uspto-grants-2016_05 |