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O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine → (S)-tert-Butyl 4-(benzyloxy)-1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)butan-2-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Benzyl-N-(tert-butoxycarbonyl)-L-homoserine | HCID 15058464 | — |
| 反応物 | 1-amino-N-phenyl-1H-pyrrole-2-carboxamide | HCID 70922454 | — |
| 生成物 | (S)-tert-Butyl 4-(benzyloxy)-1-oxo-1-(2-(phenylcarbamoyl)-1H-pyrrol-1-ylamino)butan-2-ylcarbamate | HCID 86722052 | 99.6% |
反応手順
The title compound was prepared from 1-amino-N-phenyl-1H-pyrrole-2-carboxamide (0.65 g, 3.2 mmol) and (S)-4-(benzyloxy)-2-(tert-butoxycarbonylamino)butanoic acid (1.0 g, 3.2 mmol) following the experimental procedure described in Preparation 73a. 1.57 g (96% yield) of the desired compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340547B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-46b1e72f7fd44e81986c33a8b9028987 |
| 出典メモ | uspto-grants-2016_05 |