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2-Amino-6-(trifluoromethyl)pyridine → (S)-Benzyl 1-(3-bromo-2-(6-(trifluoromethyl)pyridin-2-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-6-(trifluoromethyl)pyridine | HCID 821024 | — |
| 反応物 | (S)-Methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-Bromo-1H-Pyrrole-2-carboxylate | HCID 86722049 | — |
| 生成物 | (S)-Benzyl 1-(3-bromo-2-(6-(trifluoromethyl)pyridin-2-ylcarbamoyl)-1H-pyrrol-1-ylamino)-1-oxopropan-2-ylcarbamate | HCID 86722053 | 51% |
反応手順
The title compound was prepared from (S)-methyl 1-(2-(benzyloxycarbonylamino)propanamido)-3-bromo-1H-pyrrole-2-carboxylate (2.00 g, 4.7 mmol) and 6-(trifluoromethyl)pyridin-2-amine (3.00 g, 18.5 mmol) following the experimental procedure described in Preparation 44a. 1.32 g (51% yield) of the desired compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09340547B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-ed12ed702594484a830867559399ecc0 |
| 出典メモ | uspto-grants-2016_05 |