反応式
[CH3:1][C:2]1([CH3:31])[O:6][C:5](=[O:7])[N:4]([C:8]2[CH:24]=[CH:23][C:11]([C:12]([NH:14][NH:15][C:16]3[CH:21]=[C:20]([I:22])[CH:19]=[CH:18][N:17]=3)=O)=[CH:10][CH:9]=2)[C@H:3]1[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.CC(O)=O>>[I:22][C:20]1[CH:19]=[CH:18][N:17]2[C:12]([C:11]3[CH:23]=[CH:24][C:8]([N:4]4[C@@H:3]([C:25]5[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=5)[C:2]([CH3:1])([CH3:31])[O:6][C:5]4=[O:7])=[CH:9][CH:10]=3)=[N:14][N:15]=[C:16]2[CH:21]=1参加物
3
反応条件
- 温度
- 180 °C
実験手順
A heterogeneous mixture of (S)-4-(5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)-N′-(4-iodopyridin-2-yl)benzohydrazide (1.53 g, 2.90 mmol) in glacial AcOH (11.70 mL, 203 mmol) was heated at 180° C. for 1 hour. LC-MS indicated clean and complete conversion to the desired product. The reaction mixture was concentrated under vacuum to give the product as a yellow solid. The material was carried on to next step without purification. m/z (ESI) 511.0 (M+H)+.
出典と根拠
- ORDレコード
- ord-af41663fa01a48b881bcab3748acfe0e
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09340549B2
関連ノート
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