Methanol → Methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

HRID 525468

反応式

HRID 525468 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([C:12]([OH:14])=[O:13])[CH2:6][CH2:5]2.[CH3:15]O.S(=O)(=O)(O)O>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][CH:7]([C:12]([O:14][CH3:15])=[O:13])[CH2:6][CH2:5]2

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 190700016-Hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

生成物 1

HCID 58055117Methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate収率 100%

実験手順

To a solution of 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid (0.5 g, 3 mmol) in methanol (6 mL, 200 mmol) was added sulfuric acid (0.05 g, 0.5 mmol) and stirred over weekend. After concentration, the residue was dissolved in EtOAc and washed with water, brine and dried over Na2SO4 to give the pure product as a white solid (0.55 g, 100%). LCMS: Rt=1.17 min, m/z=207.00 [M+], 100%.

後処理

  1. concentrationAfter concentration
  2. dissolutionthe residue was dissolved in EtOAc
  3. washwashed with water, brine
  4. dry with materialdried over Na2SO4

出典と根拠

ORDレコード
ord-a7e6033a74cc4ee7948069f4f9150761
出典データセット
uspto-grants-2016_05
特許番号
US09340527B2

関連ノート

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