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HRID 525677作成日：2026年10月27日

2-(Ethylamino)ethanol → 5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(ethyl(2-hydroxyethyl)amino)nicotinamide

https://huagongshe.com/reaction/525677

反応式

関与物質

役割名称HCID仕込み量
反応物2-(Ethylamino)ethanolHCID 8072—
反応物5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamideHCID 72546089—
生成物5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(ethyl(2-hydroxyethyl)amino)nicotinamideHCID 89906841—

反応手順

The title compound was prepared in an analogous fashion to that described in Stage 22.1 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 22.2) and 2-ethylamino-ethanol to afford an off-white crystalline solid. (Reaction Time was 10 h). HPLC (Condition 4) tR=6.1 min, UPLC-MS (Condition 3) tR=1.21 min, m/z=466.2 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09340537B2
出典データセットuspto-grants-2016_05
ORD IDord-d6ba9d57208c438db20c2b19e121365b
出典メモuspto-grants-2016_05