Hydrochloric Acid → trans-3-Amino-4-methoxypyrrolidine dihydrochloride

HRID 525757ノート

反応式

HRID 525757 の反応式
[ClH:1].[NH2:2][C@H:3]1[C@H:7]([O:8][CH3:9])[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.Cl.CCO>>[ClH:1].[ClH:1].[CH3:9][O:8][C@@H:7]1[CH2:6][NH:5][CH2:4][C@H:3]1[NH2:2]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 89906581rac-tert-butyl (3R,4R)-3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride

生成物 1

HCID 67925434trans-3-Amino-4-methoxypyrrolidine dihydrochloride

実験手順

A mixture of (trans)-tert-butyl 3-amino-4-methoxypyrrolidine-1-carboxylate hydrochloride (0.5 g, 1.939 mmol) and HCl in EtOH (15.51 mL, 19.39 mmol) was stirred at RT for 24 h. The solvent was evaporated off under reduced pressure to give the title compound.

後処理

  1. customThe solvent was evaporated off under reduced pressure

出典と根拠

ORDレコード
ord-84f24c5cc7c54af8a3e6cfe8c58b6d4e
出典データセット
uspto-grants-2016_05
特許番号
US09340537B2

反応ノート

読み込み中…