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Valproic Acid → (R)-N5-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N2-(1-oxo-2-propylpentyl)-ornithinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Valproic Acid | HCID 3121 | — |
| 反応物 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 反応物 | (R)-N5-[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl)-ornithinamide | HCID 136381090 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (R)-N5-[Amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-N2-(1-oxo-2-propylpentyl)-ornithinamide | HCID 136381110 | 65% |
反応手順
Prepared analogously to Example 5d), but using tetrahydrofuran instead of acetonitrile, from (R)-N5 -[amino(nitroimino)methyl]-N-[(4-hydroxyphenyl)methyl]-ornithinamide, 2-propyl-pentanoic acid and TBTU in a yield of 65% of theory. Colourless crystalline substance which was further processed without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616620 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-6015da7a28fd4a88b0e39061f1a3dbc5 |
| 出典メモ | uspto-grants-1997_04 |