Hydrochloric Acid → 6-Amino-2,3-dimethoxybenzoic acid hydrochloride

反応式

C(OC([NH:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[C:13]([O:18][CH3:19])[C:12]([O:20][CH3:21])=[CH:11][CH:10]=1)=O)(C)(C)C.[ClH:22].O1CCOCC1>>[ClH:22].[NH2:8][C:9]1[C:14]([C:15]([OH:17])=[O:16])=[C:13]([O:18][CH3:19])[C:12]([O:20][CH3:21])=[CH:11][CH:10]=1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 312751,4-Dioxane

HCID 144163466-((Tert-butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid

生成物 1

HCID 1317355906-Amino-2,3-dimethoxybenzoic acid hydrochloride収率 91%

実験手順

6-((tert-Butoxycarbonyl)amino)-2,3-dimethoxybenzoic acid (39 g, 131 mmol) was treated with HCl in dioxane (4N, 300 mL, 1200 mmol) at r.t. and the mixture was stirred at r.t. for 3 h. LCMS indicated completion of the reaction. The solid was collected by filtration, washed with ethyl ether and dried to afford 6-amino-2,3-dimethoxybenzoic acid, Hydrochloride (28.5 g, 120 mmol, 91% yield) as a white solid. LCMS: (M+H)+: 198.2.