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Tetrahydrofuran → 2,2-Diphenylethylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-[[[(2,2-Diphenylethyl)amino]carbonyl]amino]benzenemethylamine | HCID 18975927 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2,2-Diphenylethylamine | HCID 77575 | — |
| 生成物 | 4-Cyanophenyl isocyanate | HCID 170380 | — |
| 生成物 | 4-cyanophenyl-N'-(2,2-diphenylethyl)-urea | HCID 3849823 | — |
反応手順
Prepared, analogously to Example 13a) but using dichloromethane as solvent instead of tetrahydrofuran and without using triethylamine, from 4-[[[(2,2-diphenylethyl)amino]carbonyl]amino]benzenemethylamine (mp.: 161°-163° C.; obtained from 4-cyanophenylisocyanate and 2,2-diphenylethylamine via N-(4-cyanophenyl-N'-(2,2-diphenylethyl)-urea, mp.: 235°-237° C., and finally by catalytic hydrogenation in the presence of Raney nickel and ammonia), (R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine, DCC and HOBt in a yield of 48% of theory.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616620 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-3c374c14aa324310b266ecde97c37001 |
| 出典メモ | uspto-grants-1997_04 |