4-Bromophenol → p-Bromophenyl octyl ether

HRID 525975

反応式

HRID 525975 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 78084-BromophenolHCID 81401-BromooctaneHCID 11430Potassium Carbonate

生成物 1

HCID 145298p-Bromophenyl octyl ether収率 87.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-bromophenol (10.46 g, 60.5 mmol), 1-bromooctane (15.43 g, 79.9 mmol) and potassiumcarbonate (90 g, 0.65 mol) in N,N-dimethylformamide and was heated to 90° C. for 4 h and then the potassiumcarbonate was filtered off. The reaction mixture was quenched with water and extracted three times with ether. The ether was then washed three times with 1M hydrochloric acid (HCl), one time with water, evaporated, and purified by distillation to obtain 1-bromo-4-(octyloxy)benzene (15.1 g, 52.9 mmol) as a colourless oil.

後処理

  1. filtrationthe potassiumcarbonate was filtered off
  2. customThe reaction mixture was quenched with water
  3. extractionextracted three times with ether
  4. washThe ether was then washed three times with 1M hydrochloric acid (HCl), one time with water
  5. customevaporated
  6. distillationpurified by distillation

出典と根拠

ORDレコード
ord-cba53612026d4ccf92bb37ba1bbffbd2
出典データセット
uspto-grants-2016_05
特許番号
US09343198B2

関連ノート

読み込み中…