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Hydrochloric Acid → 2,4-Diaminoquinazoline-6-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Cyanide | HCID 9032 | — |
| 反応物 | 2,4,6-Triaminoquinazoline | HCID 292661 | — |
| 反応物 | Sodium Nitrite | HCID 23668193 | — |
| 触媒 | Copper sulfate pentahydrate | HCID 24463 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2,4-Diaminoquinazoline-6-carbonitrile | HCID 282699 | — |
反応手順
The 2,4,6-triaminoquinazoline derivatives described above may then optionally be treated with 2N hydrochloric acid, sodium nitrite, potassium cyanide, and copper(II) sulfate pentahydrate in water, affording the corresponding 2,4-diamino-6-cyanoquinazoline, for example, 2,4-diamino-6-cyano-5-methylquinazoline. Step A of Example 14 describes in detail this step in the reaction sequence.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616718 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-7093a7fae48f41c8aee7b43ad15a91f4 |
| 出典メモ | uspto-grants-1997_04 |