化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Carbonate → 2-Amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 3,5-Dichlorophenylboronic acid | HCID 2734331 | — |
| 反応物 | 6-Amino-3-bromo-2-chlorobenzonitrile | HCID 54385084 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile | HCID 54101721 | 63.9% |
反応手順
This compound was prepared in a manner analogous to that of Step D of Example 1, using 2.3 grams (0.010 mole) of 2-amino-5-bromo-6-chlorobenzonitrile (prepared as in Step A of Example 2), 2.9 grams (0.015 mole) of 3,5-dichlorophenylboronic acid, 0.1 gram (catalyst) of tetrakis(triphenylphosphine)palladium(0), and 30 mL of aqueous 2M sodium carbonate in 75 mL of toluene. The solid product was recrystallized from toluene, yielding 1.9 grams of 2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile. The NMR spectrum was consistent with the proposed structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616718 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-0d644f32164c41a88910cfe52f7390a7 |
| 出典メモ | uspto-grants-1997_04 |