Chloroformamidinium chloride → 2,4-Diamino-5-chloro-6-(3,5-dichlorophenyl)quinazoline

HRID 52627

反応式

HRID 52627 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[C:12]([Cl:17])[CH:11]=2)=[C:6]([Cl:18])[C:3]=1[C:4]#[N:5].Cl.Cl[C:21]([NH2:23])=[NH:22]>COCCOCCOC>[NH2:23][C:21]1[N:22]=[C:4]([NH2:5])[C:3]2[C:2](=[CH:9][CH:8]=[C:7]([C:10]3[CH:11]=[C:12]([Cl:17])[CH:13]=[C:14]([Cl:16])[CH:15]=3)[C:6]=2[Cl:18])[N:1]=1

参加物

4

反応物 2

HCID 3084509Chloroformamidinium chlorideHCID 541017212-Amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile

生成物 1

HCID 543849132,4-Diamino-5-chloro-6-(3,5-dichlorophenyl)quinazoline収率 29.4%

試薬・触媒・溶媒 1

HCID 8150Diglyme溶媒

実験手順

This compound was prepared in a manner analogous to that of Step E of Example 1, using 1.5 grams (0.005 mole) of 2-amino-6-chloro-5-(3,5-dichlorophenyl)benzonitrile and 0.7 gram (0.006 mole) of chloroformamidine hydrochloride in 10 mL of 2-methoxyethyl ether. The solid was recrystallized from methanol, yielding 0.5 gram of 2,4-diamino-5-chloro-6-(3,5-dichlorophenyl)quinazoline. The NMR spectrum was consistent with the proposed structure; however, methanol was present in the sample.

後処理

  1. customThis compound was prepared in a manner analogous to that of Step E of Example 1
  2. customThe solid was recrystallized from methanol

出典と根拠

ORDレコード
ord-73bccbad75c74e298e026e0e79250f82
出典データセット
uspto-grants-1997_04
特許番号
US05616718

関連ノート

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