Trifluoroacetic acid → HCID 131732882、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	Trifluoroacetic acid	HCID 6422	—
反応物	N-benzyl-6-hydrazinylpyridine-3-carboxamide	HCID 51370238	—
反応物	Methyl 3-(dimethylamino)-2-(2-pyridinyl)-2-propenoate	HCID 73047442	—
溶媒	Ethanol	HCID 702	—
溶媒	Ethyl Acetate	HCID 8857	—
生成物	HCID 131732882	HCID 131732882	73.4%

反応手順

Combined N-benzyl-6-hydrazinylnicotinamide (200 mg, 0.826 mmol), methyl 3-(dimethylamino)-2-(pyridin-2-yl)acrylate (170 mg, 0.826 mmol) and TFA (0.127 mL, 1.651 mmol) in ethanol (3 mL) and stirred overnight at room temperature. The reaction mixture was diluted in EtOAc (50 mL), washed with saturated aqueous sodium bicarbonate (20 ml), brine (20 ml), dried with Na2SO4 and concentrated to give the title compound (244 mg) as an orange solid, was used without further purification. MS m/z [M+H]+ 404.4.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09345713B2
出典データセット	uspto-grants-2016_05
ORD ID	ord-fb94b72e70be42fabc156342cd64610e
出典メモ	uspto-grants-2016_05