Hydrochloric Acid → Hydrochloric Acid
反応式
[CH:1]1([N:5]([CH3:17])[CH:6]2[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]2)[CH2:4][CH2:3][CH2:2]1.[ClH:18].O1CCOCC1>C(Cl)Cl>[CH:1]1([N:5]([CH3:17])[CH:6]2[CH2:9][NH:8][CH2:7]2)[CH2:4][CH2:3][CH2:2]1.[ClH:18]参加物
6
反応条件
- 温度
- 20 °C
実験手順
Combined a solution of tert-butyl 3-(cyclobutyl(methyl)amino)azetidine-1-carboxylate (285 mg, 1.186 mmol) in methylene chloride (6 mL) and added 4 M HCl in dioxane (1.186 mL, 4.74 mmol) and the solution stirred at 20° C. for 30 h. The solution was concentrated in vacuo and concentrated from heptane/methylene chloride to give the title compound as a hydrochloride acid salt (191 mg, 0.896 mmol, 76%) as a light yellow solid which was used without further purification.
後処理
- concentrationThe solution was concentrated in vacuo
- concentrationconcentrated from heptane/methylene chloride
出典と根拠
- ORDレコード
- ord-bc9347c20b774fa7aa4146d51e08ec83
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09345713B2
反応ノート
読み込み中…