化工社化工社 化学情報印刷レポート · 研究参考用
2-Amino-6-methylbenzonitrile → Quinazoline, 2,4-diamino-5-methyl-(7CI,8CI)
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-6-methylbenzonitrile | HCID 279973 | — |
| 反応物 | Chloroformamidinium chloride | HCID 3084509 | — |
| 溶媒 | Diglyme | HCID 8150 | — |
| 生成物 | Quinazoline, 2,4-diamino-5-methyl-(7CI,8CI) | HCID 198062 | 86.9% |
反応手順
This compound was prepared in a manner analogous to that of Step E of Example 1, using 10.0 grams (0.076 mole) of 2-amino-6-methylbenzonitrile (prepared as in Example 1, Step B), and 10.0 grams (0.087 mole) of chloroformamidine hydrochloride in 40 mL of 2-methoxyethyl ether, yielding 11.5 grams of 2,4-diamino-5-methylquinazoline. The NMR spectrum was consistent with the proposed structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616718 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-5bff3e82ae1c49429521657f681739cb |
| 出典メモ | uspto-grants-1997_04 |