Hydrochloric Acid → 3-(4-isopropoxyphenyl)-1H-pyrazole-4-carbaldehyde hydrochloride
反応式
[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:15]([CH:16]=[O:17])=[CH:14][N:13](C3CCCCO3)[N:12]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[ClH:24]>>[ClH:24].[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:15]([CH:16]=[O:17])=[CH:14][NH:13][N:12]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2]参加物
3
実験手順
A solution of 3-(4-isopropoxyphenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carbaldehyde (7.4 g, 23.56 mmol) in 3M methanolic HCl (74 mL) was stirred at rt for 3 h. The resulting solution was concentrated and triturated using diethyl ether (50 mL×3) to afford 3-(4-isopropoxyphenyl)-1H-pyrazole-4-carbaldehyde hydrochloride (5.3 g, yield 98%). LCMS (method C): RT=1.96 min, m/z=231.1 [M+H]+.
後処理
- concentrationThe resulting solution was concentrated
- customtriturated
出典と根拠
- ORDレコード
- ord-0aea8fd604964b55b591db98cba9c097
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09346761B2
反応ノート
読み込み中…