関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Hydroxide | HCID 14923 | — |
| 反応物 | 1-Methyl-1,2-epoxycyclohexane | HCID 224243 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Amino-1-methylcyclohexan-1-ol | HCID 20365030 | — |
反応手順
To a solution of 1-methyl-7-oxabicyclo[4.1.0]heptane, 30a, (1.0 g, 7.1 mmol) in water was added ammonium hydroxide (6.0 mL, 154.1 mmol). The mixture was heated to 50° C. for 48 hours. The mixture was diluted with water, extracted with EtOAc and then twice with 20% MeOH/CHCl3. The organic phases were dried (MgSO4), filtered and concentrated in vacuo to provide the desired product, 30b, as an amorphous white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09345708B2 |
|---|
| 出典データセット | uspto-grants-2016_05 |
|---|
| ORD ID | ord-b67315c040f44fbba5c5f73e9b24f4e5 |
|---|
| 出典メモ | uspto-grants-2016_05 |
|---|
