関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 3-Bromo-2-chloro-6-methylpyridine | HCID 2734418 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 3-Bromo-6-(bromomethyl)-2-chloropyridine | HCID 57984510 | — |
反応手順
In 21 mL of carbon tetrachloride, 3-bromo-2-chloro-6-methylpyridine (880 mg, 4.26 mmol) was dissolved, and N-bromosuccinimide (682 mg, 3.83 mmol) and AIBN (70 mg, 0.426 mmol) were added, followed by stirring at 90° C. for one hour. The resulting reaction solution was concentrated, and the residue thus obtained was purified by silica gel column chromatography (chloroform/methanol=100/0 to 95/5), whereby 3-bromo-6-(bromomethyl)-2-chloropyridine was obtained as a crude purified product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09346787B2 |
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| 出典データセット | uspto-grants-2016_05 |
|---|
| ORD ID | ord-753727f860cb43a9b55d455bf339e35d |
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| 出典メモ | uspto-grants-2016_05 |
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