Methamidophos → Acephate

HRID 52751

反応式

HRID 52751 の反応式
[P:1](=[O:7])([NH2:6])([S:4][CH3:5])[O:2][CH3:3].[C:8](OC(=O)C)(=[O:10])[CH3:9]>S(OC)(OC)(=O)=O>[C:8]([NH:6][P:1](=[O:7])([S:4][CH3:5])[O:2][CH3:3])(=[O:10])[CH3:9]

参加物

4

反応物 2

HCID 4096MethamidophosHCID 7918Acetic Anhydride

生成物 1

HCID 1982Acephate収率 138.1%

試薬・触媒・溶媒 1

HCID 6497Dimethyl Sulfate触媒

実験手順

19.1 Grams of dimethyl sulfate were gradually added to 296 g(purity 86.3%) of O,O-dimethylphosphoramidothioate at 40° C. in 30 min and to the resultant were further added 1180 g of O,O-dimethyl phosphoramidothioate and 76.1 g of dimethyl sulfate at the same temperature over 2 hours separately. The resultant reaction mixture was further maintained at the temperature for 8 hours to obtain 1562 g of O,S-dimethyl phosphoramidothioate(purity: 79.1%). To 1562 g of obtained O,S-dimethyl phosphoramidothioate was added 1218 g of acetic anhydride and 41 g of dimethyl sulfate at 40° C. over an hour. The resultant was maintained at the temperature for an hour to complete the reaction to give 2799 g of crude O,S-dimethyl N-acetylphosphoramidothioate(purity: 49.13%).

後処理

  1. temperatureThe resultant was maintained at the temperature for an hour
  2. customthe reaction

出典と根拠

ORDレコード
ord-a3ad99f2baca4e2199d0e9d44b019ec8
出典データセット
uspto-grants-1997_04
特許番号
US05616769

関連ノート

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