Acetic Anhydride → 1-(2,6-dihydroxyphenyl)ethanone O-acetyloxime

HRID 527512ノート

反応式

HRID 527512 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[N:11][OH:12])[CH3:10].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([O:12][N:11]=[C:9]([C:3]1[C:4]([OH:8])=[CH:5][CH:6]=[CH:7][C:2]=1[OH:1])[CH3:10])(=[O:15])[CH3:14]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 1363786461-(2,6-Dihydroxyphenyl)ethanone oxime2 回

生成物 1

HCID 1363786471-(2,6-dihydroxyphenyl)ethanone O-acetyloxime収率 59.4%

実験手順

To 1-(2,6-dihydroxyphenyl)ethanone oxime (Intermediate 8, 588 mg), acetic anhydride (1.97 ml, 20.8 mmol) was added and the reaction mixture was stirred at room temperature for 15 minutes. After the removal of the volatiles, water was added and the solid obtained was filtered and dried under high vacuum affording 437 mg of the title compound.

後処理

  1. customAfter the removal of the volatiles, water
  2. additionwas added
  3. customthe solid obtained
  4. filtrationwas filtered
  5. customdried under high vacuum

出典と根拠

ORDレコード
ord-e39ded6122ea445fb41a33891a373300
出典データセット
uspto-grants-2016_05
特許番号
US09346790B2

反応ノート

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