Hydrochloric Acid → 1-(2,6-Dihydroxyphenyl)-propan-1-one

HRID 527524ノート

反応式

HRID 527524 の反応式
COC[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11]COC)[C:6]=1[C:15](=[O:18])[CH2:16][CH3:17].Cl>CO>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:6]=1[C:15](=[O:18])[CH2:16][CH3:17]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 22614991HCID 22614991、化合物2 回

生成物 1

HCID 116223911-(2,6-Dihydroxyphenyl)-propan-1-one収率 99.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-(2,6-bis{[(methyloxy)methyl]oxy}phenyl)-1-propanone (Intermediate 27, 1.7 g) was dissolved in methanol (50.0 ml) and an aqueous solution of HCl (26.7 ml, 53.5 mmol of a 2M aqueous solution) was added. The reaction mixture was refluxed for 2 hours. After quenching with water, the reaction mixture was extracted with ethyl acetate. The gathered organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound (1.11 g).

後処理

  1. temperatureThe reaction mixture was refluxed for 2 hours
  2. customAfter quenching with water
  3. extractionthe reaction mixture was extracted with ethyl acetate
  4. dry with materialThe gathered organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-4384d7b35b4c45d1a8745f02dca65394
出典データセット
uspto-grants-2016_05
特許番号
US09346790B2

反応ノート

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