Acetic Anhydride → HCID 136378652、化合物

HRID 527526ノート

反応式

HRID 527526 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:9](=[N:12][OH:13])[CH2:10][CH3:11].[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[C:14]([O:13][N:12]=[C:9]([C:3]1[C:4]([OH:8])=[CH:5][CH:6]=[CH:7][C:2]=1[OH:1])[CH2:10][CH3:11])(=[O:16])[CH3:15]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 136378651HCID 136378651、化合物2 回

生成物 1

HCID 136378652HCID 136378652、化合物収率 30.5%

実験手順

1-(2,6-dihydroxyphenyl)-1-propanone oxime (Intermediate 29, 716 mg) was stirred in acetic anhydride (2.24 ml, 23.7 mmol) at room temperature for 1 hour. After removal of the volatiles, the residue was washed with water, filtered and dried. The crude compound was charged on a silica gel column (Biotage SP1 system) and eluted with Cyclohexane/EtOAc (from 100/0 to all 0/100) to afford the title compound (269 mg).

後処理

  1. customAfter removal of the volatiles
  2. washthe residue was washed with water
  3. filtrationfiltered
  4. customdried
  5. additionThe crude compound was charged on a silica gel column (Biotage SP1 system)
  6. washeluted with Cyclohexane/EtOAc (from 100/0 to all 0/100)

出典と根拠

ORDレコード
ord-62ce0eca3bda4c52840c4cf170ea354d
出典データセット
uspto-grants-2016_05
特許番号
US09346790B2

反応ノート

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