Stannous chloride dihydrate → 6-[(3-Ethyl-1,2-benzisoxazol-4-yl)oxy]-3-pyridinamine

HRID 527528ノート

反応式

HRID 527528 の反応式
[CH2:1]([C:3]1[C:7]2[C:8]([O:12][C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][N:14]=3)=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][N:4]=1)[CH3:2].O.O.[Sn](Cl)Cl>C(O)C>[CH2:1]([C:3]1[C:7]2[C:8]([O:12][C:13]3[N:14]=[CH:15][C:16]([NH2:19])=[CH:17][CH:18]=3)=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][N:4]=1)[CH3:2]

参加物

4

反応物 2

HCID 61436Stannous chloride dihydrateHCID 679599933-Ethyl-4-[(5-nitro-2-pyridinyl)oxy]-1,2-benzisoxazole2 回

生成物 1

HCID 679605196-[(3-Ethyl-1,2-benzisoxazol-4-yl)oxy]-3-pyridinamine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

3-ethyl-4-[(5-nitro-2-pyridinyl)oxy]-1,2-benzisoxazole (Intermediate 32, 9 mg) was dissolved in 3.0 ml of ethanol. Then tin(II) chloride dihydrate (21.4 mg, 0.095 mmol) was added and the reaction mixture was stirred at 80° C. for 3 hours. After quenching with water and extraction with ethyl acetate, the organic phase was dried over sodium sulphate, filtered and evaporated to afford the title compound.

後処理

  1. customAfter quenching with water and extraction with ethyl acetate
  2. dry with materialthe organic phase was dried over sodium sulphate
  3. filtrationfiltered
  4. customevaporated

出典と根拠

ORDレコード
ord-c13be8d01eee4b52a91eb1aa757d30bb
出典データセット
uspto-grants-2016_05
特許番号
US09346790B2

反応ノート

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